Covid-19: New variant with potentially worrying mutations found in UK, with other cases in countries including Denmark, US and Australia



Article By: Nicola Davis

Variant detected in 10 countries, with 32 cases identified in United Kingdom, say researchers



Another coronavirus variant with a potentially worrying set of mutations has been detected in 10 countries, including the UK.

Researchers at the University of Edinburgh said the variant, known as B1525, has been detected through genome sequencing in countries including Denmark, the United States and Australia. Some 32 cases have been identified in the UK so far.

The earliest sequences were dated to December and cropped up in the UK and Nigeria, the scientists said.

The team reported the variant has similarities in its genome to the Kent variant, B117, and it contains a number of worrying mutations, including the E484K mutation to the spike protein – found on the outside of the virus that plays an important role in helping it enter cells.

This mutation is present in variants that emerged in South Africa and Brazil and is thought to make the virus better able to evade neutralising antibodies produced by the body.

Dr Simon Clarke, an associate professor of cellular microbiology at the University of Reading, said that while it was unclear what effect many of the mutations may have on the ability of the coronavirus to establish an infection or on the severity of disease, the presence of the E484K mutation was known in the South African variant to confer a degree of resistance to some vaccines.

“We don’t yet know how well this [new] variant will spread, but if it is successful it can be presumed that immunity from any vaccine or previous infection will be blunted,” he said.

Surge testing
Dr Clarke added that the new variant should be included in efforts to boost testing to pick up variants of concern: “I think that until we know more about these variants, any variants which carry E484K should be subject to surge testing as it seems to confer resistance to immunity, however that is generated.”

Surge testing is the rollout of additional community testing of people who do not have symptoms of coronavirus, with the aim of helping scientists learn more about different variants of Covid-19.

Prof Ravi Gupta, a professor of clinical microbiology at the University of Cambridge, agreed surge testing for the new variant was warranted. He said as well as the E484K mutation, the variant had another change “that likely helps it escape from our antibodies”.

But Prof Jonathan Stoye, a group leader at the Francis Crick Institute, said that while the variant was clearly spreading, surge testing had problems, including that those most at risk of spreading Covid may not come forward, for example because they cannot afford financially to test positive.

Prof Stoye said it was not surprising that the new variant contained some familiar mutations. “The minute you start putting selection pressure on this virus, you start selecting particularly for things that give it the ability to escape immune responses, and I think that is what we are seeing here,” he said.

Vaccine tweaks
But the discovery that several variants of concern share the same mutations means tweaks to the current Covid vaccines would be expected to offer protection against multiple new variants. “This [E484K] change seems to be the key change at the moment to allow escape, so that’s the one you put into the tweaked vaccine,” said Prof Stoye.

Dr Lucy van Dorp, from the Genetics Institute at University College London, said rapid detection of new variants was crucial. “One of the major advantages of genomic surveillance is to pick up lineages of potential concern early, while still at low frequency, to allow quick assessment and evaluation of their impact and prevalence in other regions of the world,” she said.



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